ABL Exon 4 Primer Set (B)
The ABL proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Mutations in the ABL gene are associated with chronic myelogenous leukemia (CML), where it is activated by being translocated within the BCR (breakpoint cluster region) gene on chromosome 22. The BCR-ABL transcript encodes a tyrosine kinase, which activates mediators of the cell cycle regulation system, leading to a clonal myeloproliferative disorder. ABL exon 4 primer set have the function to enrich mutation type of ABL gene and allows to detect target codons Q252, Y253 and E255 on DNA samples.
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Product Specification
- Gene Name
ABL Abelson murine leukemia viral oncogene homolog
- Catalog
20 tests: ABL-122-0020
50 tests: ABL-122-0050 - Official Symbol
ABL
- Alternative Name
ABL; ABL1; JTK7; Proto-oncogene tyrosine-protein kinase ABL1; c-ABL; p150; c-abl oncogene 1, non-receptor tyrosine kinase
- GeneID
25
- Uniprot ID
P00519
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- Target Codon
Q252 / Y253 / E255
- Gene Range
184~260 aa
- Purity Detail
Purified by High-performance liquid chromatography
- Recommend PCR Condition
95°C, 10mins;
94°C, 1mins–>65°C, 3mins–>57°C, 1mins–>72°C, 1mins (x45 cycles);
72°C, 10mins;
10°C, ∞ - Shipping Condition
4°C
- Long Term Storage
Stable for up to one year when store at -20°C. Avoid freeze/thaw cycles.
- Data
- Datasheet
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02
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